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			PubMed Journals: J Allergy Clin Immunol

  Source:		PMID: 9867498
  Download:	https://www.jacionline.org/article/S0091-6749(98)70008-9/pdf

    		J Allergy Clin Immunol. 1998 Nov;102(5):714-8.
     
			Epithelia cells as regulators of airway
			inflammation.

			Polito AJ(1), Proud D.

			Author Information
			(1) Department of Medicine, Division of
			Pulmonary & Critical Care Medicine, Johns Hopkins University
			School of Medicine, Baltimore, MD 21224-6801,
			USA.

			The past decade has seen major advances
			in our understanding of the metabolic and
			biochemical functions of the epithelial
			cell. As a result, the traditional view
			of the epithelium as a relatively passive
			physical barrier to the internal environment
			has been superseded by the concept that
			the epithelial plays a key role in regulating
			airway inflammation. The epithelial cell
			experts this modulatory effect in several
			ways. Epithelial cells can function maintain
			mucosal integrity and to modulate local
			immune responses. They can also limit inflammatory
			processes by degrading, or inhibiting,
			proinflammatory mediators and proteins.
			However, the epithelium also responds to
			a range of stimuli by producing biologically
			active mediators that can influence airway
			inflammation. These include, but are not
			limited to a broad range of cytokines and
			chemokines that can exert profound effects
			on inflammatory cells, as well as lipid
			and peptide mediators. This review will
			highlight some of these aspects of the role
			of the epithelium in regulating airway inflammation.

			PMID: 9867498 [Indexed for MEDLINE]

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