PubMed Journals: Acta Biol Med Ger
Source: PMID: 7340337
⇦ ⇨ Acta Biol Med Ger. 1981;40(9):1139-43.
Action of rat liver cathepsin L on glucagon.
Kärgel HJ, Dettmer R, Etzold G, Kirschke
H, Bohley P, Langner J.
The proteolytic specificity of cathepsin
L on glucagon was determined. Major cleavages
are found between Thr7 and Ser8, Asp15 and
Ser16, and between Met27 and Asn28. The
bonds Ser11-Lys12, Val23-Gln24, and Gln24-Trp25
are hydrolyzed to a relatively low extent
only. Whereas cathepsin B hydroxyzes glucagon
at the C-terminus by a peptidyldipeptidase
mechanism, cathepsin L cleaves the same
substrate clearly as endopeptidase.
PMID: 7340337 [Indexed for MEDLINE]