*nlm.life
			PubMed Journals: Acta Biol Med Ger

  Source:		PMID: 7340337


    		Acta Biol Med Ger. 1981;40(9):1139-43.
     
			Action of rat liver cathepsin L on glucagon.

			Kärgel HJ, Dettmer R, Etzold G, Kirschke
			H, Bohley P, Langner J.

			The proteolytic specificity of cathepsin
			L on glucagon was determined. Major cleavages
			are found between Thr7 and Ser8, Asp15 and
			Ser16, and between Met27 and Asn28. The
			bonds Ser11-Lys12, Val23-Gln24, and Gln24-Trp25
			are hydrolyzed to a relatively low extent
			only. Whereas cathepsin B hydroxyzes glucagon
			at the C-terminus by a peptidyldipeptidase
			mechanism, cathepsin L cleaves the same
			substrate clearly as endopeptidase.

			PMID: 7340337 [Indexed for MEDLINE]

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