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			PubMed Journals: Front Immunol

  Source:		PMID: 32117225


    		Front Immunol. 2020 Jan 24;11:26. doi:
     		10.3389/fimmu.2020.00026. eCollection 2020.

			Novel Insights Into Immune Systems of Bats.


			Banerjee A(1), Baker ML(2), Kulcsar K(3), Misra
			V(4), Plowright R(5), Mossman K(1).

			Author Information
			(1) Department of Pathology and Molecular
			Medicine, Michael DeGroote Institute for
			Infectious Disease Research, McMaster
			Immunology Research Centre,
			McMaster University, Hamilton, ON, Canada.
			(2) Health and Biosecurity Business Unit,
			Australian Animal Health Laboratory, CSIRO,
			Geelong, VIC, Australia.
			(3) Department of Microbiology and
			Immunology, University of Maryland School of
			Medicine, Baltimore, MD, United States.
			(4) Department of Veterinary Microbiology,
			Western College of Veterinary Medicine,
			University of Saskatchewan, Saskatoon, SK,
			Canada.
			(5) Department of Microbiology and
			Immunology, Montana State University,
			Bozeman, MT, United States.

			In recent years, viruses similar to those that
			cause serious disease in humans and other
			mammals have been detected in apparently
			healthy bats. These include filoviruses,
			paramyxoviruses, and coronaviruses that cause
			severe diseases such as Ebola virus disease,
			Marburg haemorrhagic fever and
			severe acute respiratory syndrome (SARS) in
			humans. The evolution of flight in bats seem to
			have selected for a unique set of antiviral
			immune responses that control virus
			propagation, while limiting self-damaging
			inflammatory responses. Here, we summarize
			our current understanding of antiviral immune
			responses in bats and discuss their ability to
			co-exist with emerging viruses that cause
			serious disease in other mammals. We highlight
			how this knowledge may help us to predict viral
			spillovers into new hosts and discuss future
			directions for the field.

			Copyright © 2020 Banerjee, Baker, Kulcsar,
			Misra, Plowright and Mossman.

			DOI: 10.3389/fimmu.2020.00026
			PMCID: PMC7025585 PMID: 32117225

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