PubMed Journals: Front Immunol
Source: PMID: 32117225
⇦ ⇨ Front Immunol. 2020 Jan 24;11:26. doi:
⇩ 10.3389/fimmu.2020.00026. eCollection 2020.
Novel Insights Into Immune Systems of Bats.
Banerjee A(1), Baker ML(2), Kulcsar K(3), Misra
V(4), Plowright R(5), Mossman K(1).
(1) Department of Pathology and Molecular
Medicine, Michael DeGroote Institute for
Infectious Disease Research, McMaster
Immunology Research Centre,
McMaster University, Hamilton, ON, Canada.
(2) Health and Biosecurity Business Unit,
Australian Animal Health Laboratory, CSIRO,
Geelong, VIC, Australia.
(3) Department of Microbiology and
Immunology, University of Maryland School of
Medicine, Baltimore, MD, United States.
(4) Department of Veterinary Microbiology,
Western College of Veterinary Medicine,
University of Saskatchewan, Saskatoon, SK,
(5) Department of Microbiology and
Immunology, Montana State University,
Bozeman, MT, United States.
In recent years, viruses similar to those that
cause serious disease in humans and other
mammals have been detected in apparently
healthy bats. These include filoviruses,
paramyxoviruses, and coronaviruses that cause
severe diseases such as Ebola virus disease,
Marburg haemorrhagic fever and
severe acute respiratory syndrome (SARS) in
humans. The evolution of flight in bats seem to
have selected for a unique set of antiviral
immune responses that control virus
propagation, while limiting self-damaging
inflammatory responses. Here, we summarize
our current understanding of antiviral immune
responses in bats and discuss their ability to
co-exist with emerging viruses that cause
serious disease in other mammals. We highlight
how this knowledge may help us to predict viral
spillovers into new hosts and discuss future
directions for the field.
Copyright © 2020 Banerjee, Baker, Kulcsar,
Misra, Plowright and Mossman.
PMCID: PMC7025585 PMID: 32117225