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			PubMed Journals: Lancet Infect Dis

  Source:		PMID: 32105637


    		Lancet Infect Dis. 2020 Feb 24. pii:
     		S1473-3099(20)30086-4. doi:
			10.1016/S1473-3099(20)30086-4. [Epub
			ahead of print]

			Radiological findings from 81 patients with
			COVID-19 pneumonia in Wuhan, China: a
			descriptive study.

			Shi H(1), Han X(1), Jiang N(1), Cao Y(1), Alwalid
			O(1), Gu J(1), Fan Y(2), Zheng C(3).

			Author Information
			(1) Department of Radiology, Union Hospital,
			Tongji Medical College,
			Huazhong University of Science and Technology,
			Wuhan, Hubei, China; Hubei Province Key
			Laboratory of Molecular Imaging, Wuhan,
			Hubei, China.
			(2) Department of Radiology, Wuhan Jinyintan
			Hospital, Wuhan, Hubei, China. Electronic
			address: 1024932023@qq.com.
			(3) Department of Radiology, Union Hospital,
			Tongji Medical College, Huazhong University of
			Science and Technology, Wuhan, Hubei, China;
			Hubei Province Key Laboratory of Molecular
			Imaging, Wuhan, Hubei, China. Electronic
			address: hqzcsxh@sina.com.

			BACKGROUND: A cluster of patients with
			coronavirus disease 2019 (COVID-19)
			pneumonia caused by infection with
			severe acute respiratory syndrome coronavirus
			2 (SARS-CoV-2) were successively reported in
			Wuhan, China. We aimed to describe the CT
			findings across different timepoints throughout
			the disease course. METHODS: Patients with
			COVID-19 pneumonia (confirmed by
			next-generation sequencing or RT-PCR) who
			were admitted to one of two hospitals in
			Wuhan and who underwent serial chest CT
			scans were retrospectively enrolled. Patients
			were grouped on the basis of the interval
			between symptom onset and the first CT scan:
			group 1 (subclinical patients; scans done before
			symptom onset), group 2 (scans done ≤1 week
			after symptom onset), group 3 (>1 week to 2
			weeks), and group 4 (>2 weeks to 3 weeks).
			Imaging features and their distribution were
			analysed and compared across the four
			groups. FINDINGS: 81 patients admitted to
			hospital between Dec 20, 2019, and Jan 23,
			2020, were retrospectively enrolled. The cohort
			included 42 (52%) men and 39 (48%) women,
			and the mean age was 49·5 years (SD 11·0).
			The mean number of involved lung segments
			was 10·5 (SD 6·4) overall, 2·8 (3·3) in group 1,
			11·1 (5·4) in group 2, 13·0 (5·7) in group 3, and
			12·1 (5·9) in group 4. The predominant pattern of
			abnormality observed was bilateral (64 [79%]
			patients), peripheral (44 [54%]), ill-defined (66
			[81%]), and ground-glass opacification (53
			[65%]), mainly involving the right lower lobes
			(225 [27%] of 849 affected segments). In group
			1 (n=15), the predominant pattern was
			unilateral (nine [60%]) and multifocal (eight
			[53%]) ground-glass opacities (14 [93%]).
			Lesions quickly evolved to bilateral (19 [90%]),
			diffuse (11 [52%]) ground-glass opacity
			predominance (17 [81%]) in group 2 (n=21).
			Thereafter, the prevalence of ground-glass
			opacities continued to decrease (17 [57%] of
			30 patients in group 3, and five [33%] of 15 in
			group 4), and consolidation and mixed patterns
			became more frequent (12 [40%] in group 3,
			eight [53%] in group 4). INTERPRETATION:
			COVID-19 pneumonia manifests with chest CT
			imaging abnormalities, even in asymptomatic
			patients, with rapid evolution from focal
			unilateral to diffuse bilateral ground-glass
			opacities that progressed to or co-existed with
			consolidations within 1-3 weeks. Combining
			assessment of imaging features with clinical
			and laboratory findings could facilitate early
			diagnosis of COVID-19 pneumonia. FUNDING:
			None.

			Copyright © 2020 Elsevier Ltd. All rights
			reserved.

			DOI: 10.1016/S1473-3099(20)30086-4
			PMID: 32105637

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