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			PubMed Journals: J Dig Dis

  Source:		PMID: 32096611


    		J Dig Dis. 2020 Feb 25. doi:
     		10.1111/1751-2980.12851. [Epub ahead of
			print]

			2019 novel coronavirus infection and
			gastrointestinal tract.

			Gao QY(1), Chen YX(1), Fang JY(1).

			Author Information
			(1) Division of Gastroenterology and
			Hepatology, Shanghai Institute of Digestive
			Disease, Renji Hospital, School of Medicine,
			Shanghai Jiao Tong University, Shanghai,
			China.

			Since end of December 2019, a cluster of
			patients with pneumonia of unknown origin was
			reported from Wuhan, Hubei province, China.
			As of Feb 17th, 2020, statistical data show that
			the outbreak constitutes an epidemic threat in
			China, where the exponential increase in
			patients has reached 75114 confirmed cases,
			with 2239 deaths. Different from SARS-CoV
			(severe acute respiratory syndrome
			coronavirus) and MERS-CoV
			(Middle East respiratory syndrome coronavirus)
			infection, the initial presentations or the chief
			complain of some patients with the 2019 novel
			coronavirus (COVID-19) were
			gastrointestinal symptoms. So we call upon all
			the first-line medical staff to be cautious and
			pay more attention to those untypical patients
			especially from the epidemic area. Besides, as
			the viral nucleic acids could be found in the
			fecal samples and anal swabs of some patients
			with COVID-19 infection, the possibility of
			fecal-oral transmission need to be took into
			account. Based on the previously and recently
			studies, we speculate that COVID-19 may have
			some relationship with the gut microbiota
			through angiotensin-converting enzyme 2 (ACE2)
			receptor, thus targeting gut microbiota might
			be a new therapeutic option for the treatment
			of virus-related pneumonia. This article is
			protected by copyright. All rights reserved.

			This article is protected by copyright. All rights
			reserved.

			DOI: 10.1111/1751-2980.12851
			PMID: 32096611

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