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			PubMed Journals: Int J Antimicrob Agents

  Source:		PMID: 32081636


    		Int J Antimicrob Agents. 2020 Feb 17:105924.
     		doi: 10.1016/j.ijantimicag.2020.105924. [Epub
			ahead of print]

			Severe acute respiratory syndrome coronavirus
			2 (SARS-CoV-2) and coronavirus disease-2019
			(COVID-19): The epidemic and the challenges.

			Lai CC(1), Shih TP(2), Ko WC(3), Tang HJ(4),
			Hsueh PR(5).

			Author Information
			(1) Department of Internal Medicine, Kaohsiung
			Veterans General Hospital, Tainan Branch,
			Tainan, Taiwan.
			(2) Department of Family Medicine, Kaohsiung
			Veterans General Hospital, Tainan Branch,
			Tainan, Taiwan.
			(3) Department of Medicine, College of
			Medicine, National Cheng Kung University,
			Tainan, Taiwan.
			(4) Department of Medicine, Chi Mei Medical
			Center, Tainan 71004, Taiwan.
			(5) Department of Laboratory Medicine,
			National Taiwan University Hospital, National Taiwan University
			College of Medicine, Taipei, Taiwan;
			Department of Internal Medicine, National
			Taiwan University Hospital, National Taiwan
			University College of Medicine, Taipei, Taiwan.
			Electronic address: hsporen@ntu.edu.tw.

			The emergence of
			severe acute respiratory syndrome coronavirus
			2 (SARS-CoV-2; previously provisionally named
			2019 novel coronavirus or 2019-nCoV) disease
			(COVID-19) in China at the end of 2019 has
			caused a large global outbreak and is a major
			public health issue. As of 11 February 2020,
			data from the World Health Organization (WHO)
			have shown that more than 43 000 confirmed
			cases have been identified in 28
			countries/regions, with >99% of cases being
			detected in China. On 30 January 2020, the
			WHO declared COVID-19 as the sixth public
			health emergency of international concern.
			SARS-CoV-2 is closely related to two
			bat-derived severe acute respiratory
			syndrome-like coronaviruses, bat-SL-CoVZC45
			and bat-SL-CoVZXC21. It is spread by
			human-to-human transmission via droplets or
			direct contact, and infection has been
			estimated to have mean incubation period of
			6.4 days and a basic reproduction number of
			2.24-3.58. Among patients with pneumonia
			caused by SARS-CoV-2 (novel coronavirus
			pneumonia or Wuhan pneumonia), fever was
			the most common symptom, followed by
			cough. Bilateral lung involvement with
			ground-glass opacity was the most common
			finding from computed tomography images of
			the chest. The one case of SARS-CoV-2
			pneumonia in the USA is responding well to
			remdesivir, which is now undergoing a clinical
			trial in China. Currently, controlling infection to
			prevent the spread of SARS-CoV-2 is the
			primary intervention being used. However,
			public health authorities should keep monitoring
			the situation closely, as the more we can learn
			about this novel virus and its associated
			outbreak, the better we can respond.

			Copyright © 2020 Elsevier Ltd. All rights
			reserved.

			DOI: 10.1016/j.ijantimicag.2020.105924
			PMID: 32081636

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