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			PubMed Journals: Allergy

  Source:		PMID: 32077115


    		Allergy. 2020 Feb 19. doi: 10.1111/all.14238.
     		[Epub ahead of print]

			Clinical characteristics of 140 patients infected
			with SARS-CoV-2 in Wuhan, China.

			Zhang JJ(1), Dong X(1), Cao YY(2), Yuan YD(3),
			Yang YB(4), Yan YQ(5), Akdis CA(6), Gao YD(1).

			Author Information
			(1) Department of Allergology,
			Zhongnan Hospital of Wuhan University,
			Wuhan, China.
			(2) Department of Radiology, Zhongnan
			Hospital of Wuhan University, Wuhan, China.
			(3) Department of Respiratory and Critical Care
			Medicine, Second Hospital of
			Hebei Medical University, Shijiazhuang, China.
			(4) Department of Respiratory and Critical Care
			Medicine, Zhongnan Hospital of Wuhan
			University, Wuhan, China.
			(5) Department of Infectious Disease, No. 7
			Hospital of Wuhan, Wuhan, China.
			(6) Swiss Institute of Allergy and Asthma Research
			(SIAF), University of Zurich, Davos, Switzerland.

			BACKGROUND: Coronavirus disease 2019
			(COVID-19) caused by
			severe acute respiratory syndrome coronavirus
			2 (SARS-CoV-2) infection has been widely
			spread. We aim to investigate the clinical
			characteristic and allergy status of patients
			infected with SARS-CoV-2. METHODS:
			Electronic medical records including
			demographics, clinical manifestation,
			comorbidities, laboratory data, and radiological
			materials of 140 hospitalized COVID-19
			patients, with confirmed result of SARS-CoV-2
			viral infection, were extracted and analyzed.
			RESULTS: An approximately 1:1 ratio of male
			(50.7%) and female COVID-19 patients was
			found, with an overall median age of 57.0
			years. All patients were community-acquired
			cases. Fever (91.7%), cough (75.0%), fatigue
			(75.0%), and gastrointestinal symptoms
			(39.6%) were the most common clinical
			manifestations, whereas hypertension (30.0%)
			and diabetes mellitus (12.1%) were the most
			common comorbidities. Drug hypersensitivity
			(11.4%) and urticaria (1.4%) were self-reported
			by several patients. Asthma or other allergic
			diseases were not reported by any of the
			patients.
			Chronic obstructive pulmonary disease (COPD,
			1.4%) patients and current smokers (1.4%)
			were rare. Bilateral ground-glass or patchy
			opacity (89.6%) was the most common sign of
			radiological finding. Lymphopenia (75.4%) and
			eosinopenia (52.9%) were observed in most
			patients. Blood eosinophil counts correlate
			positively with lymphocyte counts in severe (r =
			.486, P < .001) and nonsevere (r = .469, P <
			.001) patients after hospital admission.
			Significantly higher levels of D-dimer,
			C-reactive protein, and procalcitonin were
			associated with severe patients compared to
			nonsevere patients (all P < .001).
			CONCLUSION: Detailed clinical investigation of
			140 hospitalized COVID-19 cases suggests
			eosinopenia together with lymphopenia may be
			a potential indicator for diagnosis. Allergic
			diseases, asthma, and COPD are not
			risk factors for SARS-CoV-2 infection. Older
			age, high number of comorbidities, and more
			prominent laboratory abnormalities were
			associated with severe patients.

			©2020 EAACI and John Wiley and Sons A/S.
			Published by John Wiley and Sons Ltd.

			DOI: 10.1111/all.14238 PMID: 32077115

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