PubMed Journals: Allergy
Source: PMID: 32077115
⇦ ⇨ Allergy. 2020 Feb 19. doi: 10.1111/all.14238.
⇩ [Epub ahead of print]
Clinical characteristics of 140 patients infected
with SARS-CoV-2 in Wuhan, China.
Zhang JJ(1), Dong X(1), Cao YY(2), Yuan YD(3),
Yang YB(4), Yan YQ(5), Akdis CA(6), Gao YD(1).
(1) Department of Allergology,
Zhongnan Hospital of Wuhan University,
(2) Department of Radiology, Zhongnan
Hospital of Wuhan University, Wuhan, China.
(3) Department of Respiratory and Critical Care
Medicine, Second Hospital of
Hebei Medical University, Shijiazhuang, China.
(4) Department of Respiratory and Critical Care
Medicine, Zhongnan Hospital of Wuhan
University, Wuhan, China.
(5) Department of Infectious Disease, No. 7
Hospital of Wuhan, Wuhan, China.
(6) Swiss Institute of Allergy and Asthma Research
(SIAF), University of Zurich, Davos, Switzerland.
BACKGROUND: Coronavirus disease 2019
(COVID-19) caused by
severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection has been widely
spread. We aim to investigate the clinical
characteristic and allergy status of patients
infected with SARS-CoV-2. METHODS:
Electronic medical records including
demographics, clinical manifestation,
comorbidities, laboratory data, and radiological
materials of 140 hospitalized COVID-19
patients, with confirmed result of SARS-CoV-2
viral infection, were extracted and analyzed.
RESULTS: An approximately 1:1 ratio of male
(50.7%) and female COVID-19 patients was
found, with an overall median age of 57.0
years. All patients were community-acquired
cases. Fever (91.7%), cough (75.0%), fatigue
(75.0%), and gastrointestinal symptoms
(39.6%) were the most common clinical
manifestations, whereas hypertension (30.0%)
and diabetes mellitus (12.1%) were the most
common comorbidities. Drug hypersensitivity
(11.4%) and urticaria (1.4%) were self-reported
by several patients. Asthma or other allergic
diseases were not reported by any of the
Chronic obstructive pulmonary disease (COPD,
1.4%) patients and current smokers (1.4%)
were rare. Bilateral ground-glass or patchy
opacity (89.6%) was the most common sign of
radiological finding. Lymphopenia (75.4%) and
eosinopenia (52.9%) were observed in most
patients. Blood eosinophil counts correlate
positively with lymphocyte counts in severe (r =
.486, P < .001) and nonsevere (r = .469, P <
.001) patients after hospital admission.
Significantly higher levels of D-dimer,
C-reactive protein, and procalcitonin were
associated with severe patients compared to
nonsevere patients (all P < .001).
CONCLUSION: Detailed clinical investigation of
140 hospitalized COVID-19 cases suggests
eosinopenia together with lymphopenia may be
a potential indicator for diagnosis. Allergic
diseases, asthma, and COPD are not
risk factors for SARS-CoV-2 infection. Older
age, high number of comorbidities, and more
prominent laboratory abnormalities were
associated with severe patients.
©2020 EAACI and John Wiley and Sons A/S.
Published by John Wiley and Sons Ltd.
DOI: 10.1111/all.14238 PMID: 32077115