PubMed Journals: J Med Virol

  Source:		PMID: 32027036

    		J Med Virol. 2020 Feb 6. doi:
     		10.1002/jmv.25700. [Epub ahead of print]

			Genomic variance of the 2019-nCoV

			Ceraolo C(1), Giorgi FM(1).

			Author Information
			(1) Department of Pharmacy and
			Biotechnology, University of Bologna, Bologna,

			There is a rising global concern for the recently
			emerged novel coronavirus (2019-nCoV). Full
			genomic sequences have been released by the
			worldwide scientific community in the last few
			weeks to understand the evolutionary origin and
			molecular characteristics of this virus. Taking
			advantage of all the genomic information
			currently available, we constructed a
			phylogenetic tree including also representatives
			of other coronaviridae, such as Bat coronavirus
			(BCoV) and severe acute respiratory syndrome.
			We confirm high sequence similarity (>99%)
			between all sequenced 2019-nCoVs genomes
			available, with the closest BCoV sequence
			sharing 96.2% sequence identity, confirming
			the notion of a zoonotic origin of 2019-nCoV.
			Despite the low heterogeneity of the
			2019-nCoV genomes, we could identify at least
			two hypervariable genomic hotspots, one of
			which is responsible for a Serine/Leucine variation
			in the viral ORF8-encoded protein. Finally, we
			perform a full proteomic comparison with other
			coronaviridae, identifying key aminoacidic
			differences to be considered for antiviral
			strategies deriving from previous
			anti-coronavirus approaches.

			©2020 Wiley Periodicals, Inc.

			DOI: 10.1002/jmv.25700 PMID: 32027036

     			                         Tweet       Print