PubMed Journals: J Biol Regul Homeost Agents

  Source:		PMID: 32013309

    		J Biol Regul Homeost Agents. 2020 Feb
     		4;34(1). doi: 10.23812/20-Editorial-Kritas.
			[Epub ahead of print]

			Mast cells contribute to coronavirus-induced
			inflammation: new anti-inflammatory strategy.

			Kritas SK(1), Ronconi G(2), Caraffa A(3),
			Gallenga CE(4), Ross R(5), Conti P(6).

			Author Information
			(1) Department of Microbiology and Infectious
			Diseases, School of Veterinary Medicine,
			Aristotle University of Thessaloniki, Macedonia,
			(2) Clinica dei Pazienti del Territorio, Fondazione
			Policlinico Gemelli, Rome, Italy.
			(3) School of Pharmacy, University of Camerino,
			Camerino, Italy.
			(4) Department of Biomedical Sciences and
			Specialist Surgery, Section of Ophthalmology,
			University of Ferrara, Ferrara, Italy.
			(5) University of Pennsylvania School of
			Veterinary Medicine, Philadelphia, PA, USA.
			(6) Postgraduate Medical School, University of
			Chieti, Chieti, Italy.

			Coronavirus, which can cause respiratory
			syndrome, to date has affected over seventeen
			thousand individuals, especially in China.
			Coronavirus is interspecies and can also be
			transmitted from man to man, with an
			incubation ranging from 1 to 14 days. Human
			coronavirus infections can induce not only mild
			to severe respiratory diseases, but also
			inflammation, high fever, cough,
			acute respiratory tract infection and dysfunction
			of internal organs that may lead to death.
			Coronavirus infection (regardless of the various
			types of corona virus) is primarily attacked by
			immune cells including mast cells (MCs), which
			are located in the submucosa of the respiratory
			tract and in the nasal cavity and represent a
			barrier of protection against microorganisms.
			Virus activate MCs which release early
			inflammatory chemical compounds including
			histamine and protease; while late activation
			provokes the generation of pro-inflammatory
			IL-1 family members including IL-1 and IL-33.
			Here, we propose for the first time that
			inflammation by coronavirus may be inhibited by
			anti-inflammatory cytokines belonging to the
			IL-1 family members.

			Copyright 2019 Biolife Sas. www.biolifesas.org.

			DOI: 10.23812/20-Editorial-Kritas
			PMID: 32013309

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