PubMed Journals: J Biol Regul Homeost Agents
Source: PMID: 32013309⇦⇨ J Biol Regul Homeost Agents. 2020 Feb
⇩ 4;34(1). doi: 10.23812/20-Editorial-Kritas.
[Epub ahead of print]
Mast cells contribute to coronavirus-induced
inflammation: new anti-inflammatory strategy.
Kritas SK(1), Ronconi G(2), Caraffa A(3),
Gallenga CE(4), Ross R(5), Conti P(6).
(1) Department of Microbiology and Infectious
Diseases, School of Veterinary Medicine,
Aristotle University of Thessaloniki, Macedonia,
(2) Clinica dei Pazienti del Territorio, Fondazione
Policlinico Gemelli, Rome, Italy.
(3) School of Pharmacy, University of Camerino,
(4) Department of Biomedical Sciences and
Specialist Surgery, Section of Ophthalmology,
University of Ferrara, Ferrara, Italy.
(5) University of Pennsylvania School of
Veterinary Medicine, Philadelphia, PA, USA.
(6) Postgraduate Medical School, University of
Chieti, Chieti, Italy.
Coronavirus, which can cause respiratory
syndrome, to date has affected over seventeen
thousand individuals, especially in China.
Coronavirus is interspecies and can also be
transmitted from man to man, with an
incubation ranging from 1 to 14 days. Human
coronavirus infections can induce not only mild
to severe respiratory diseases, but also
inflammation, high fever, cough,
acute respiratory tract infection and dysfunction
of internal organs that may lead to death.
Coronavirus infection (regardless of the various
types of corona virus) is primarily attacked by
immune cells including mast cells (MCs), which
are located in the submucosa of the respiratory
tract and in the nasalcavity and represent a
barrier of protection against microorganisms.
Virus activate MCs which release early
inflammatory chemical compounds including
histamine and protease; while late activation
provokes the generation of pro-inflammatory
IL-1 family members including IL-1 and IL-33.
Here, we propose for the first time that
inflammation by coronavirus may be inhibited by
anti-inflammatory cytokines belonging to the
IL-1 family members.
Copyright 2019 Biolife Sas. www.biolifesas.org.
DOI: 10.23812/20-Editorial-KritasPMID: 32013309⇧TweetPrint