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			PubMed Journals: Lancet

  Source:		PMID: 31986264


    		Lancet. 2020 Jan 24. pii:
     		S0140-6736(20)30183-5. doi:
			10.1016/S0140-6736(20)30183-5. [Epub
			ahead of print]

			Clinical features of patients infected with
			2019 novel coronavirus in Wuhan, China.

			Huang C(1), Wang Y(2), Li X(3), Ren L(4), Zhao
			J(5), Hu Y(6), Zhang L(1), Fan G(7), Xu J(8), Gu
			X(7), Cheng Z(9), Yu T(1), Xia J(1), Wei Y(1), Wu
			W(1), Xie X(1), Yin W(6), Li H(2), Liu M(10), Xiao
			Y(4), Gao H(11), Guo L(4), Xie J(5), Wang G(12),
			Jiang R(3), Gao Z(13), Jin Q(4), Wang J(14),
			Cao B(15).

			Author Information
			(1) Jin Yin-tan Hospital, Wuhan, China.
			(2) Department of Pulmonary and Critical Care
			Medicine, Center of Respiratory Medicine,
			National Clinical Research Center for
			Respiratory Diseases,
			China-Japan Friendship Hospital, Beijing, China;
			Institute of Respiratory Medicine,
			Chinese Academy of Medical Sciences,
			Peking Union Medical College, Beijing, China;
			Department of Respiratory Medicine,
			Capital Medical University, Beijing, China.
			(3) Clinical and Research Center of Infectious
			Diseases, Beijing Ditan Hospital, Capital
			Medical University, Beijing, China.
			(4) NHC Key Laboratory of Systems Biology of
			Pathogens and Christophe Merieux Laboratory,
			Institute of Pathogen Biology, Chinese
			Academy of Medical Sciences and Peking
			Union Medical College, Beijing, China.
			(5) Tongji Hospital, Tongji Medical College,
			Huazhong University of Science and Technology,
			Wuhan, China.
			(6) Department of Pulmonary and Critical Care
			Medicine, The Central Hospital of Wuhan,
			Tongji Medical College, Huazhong University of
			Science and Technology, Wuhan, China.
			(7) Department of Pulmonary and Critical Care
			Medicine, Center of Respiratory Medicine,
			National Clinical Research Center for
			Respiratory Diseases, China-Japan Friendship
			Hospital, Beijing, China; Institute of Clinical
			Medical Sciences, China-Japan Friendship
			Hospital, Beijing, China; Institute of Respiratory
			Medicine, Chinese Academy of Medical
			Sciences, Peking Union Medical College,
			Beijing, China.
			(8) Tsinghua University School of Medicine,
			Beijing, China.
			(9) Department of Respiratory medicine,
			Zhongnan Hospital of Wuhan University,
			Wuhan, China.
			(10) Department of Radiology, China-Japan
			Friendship Hospital, Beijing, China.
			(11) Institute of Laboratory Animal Science,
			Chinese Academy of Medical Sciences and
			Peking Union Medical College, Beijing, China.
			(12) Department of Pulmonary and Critical Care
			Medicine, Peking University First Hospital,
			Beijing, China.
			(13) Department of Pulmonary and Critical Care
			Medicine, Peking University People's Hospital,
			Beijing, China.
			(14) NHC Key Laboratory of Systems Biology of
			Pathogens and Christophe Merieux Laboratory,
			Institute of Pathogen Biology, Chinese
			Academy of Medical Sciences and Peking
			Union Medical College, Beijing, China.
			Electronic address: wangjw28@163.com.
			(15) Department of Pulmonary and Critical Care
			Medicine, Center of Respiratory Medicine,
			National Clinical Research Center for
			Respiratory Diseases, China-Japan Friendship
			Hospital, Beijing, China; Institute of Respiratory
			Medicine, Chinese Academy of Medical
			Sciences, Peking Union Medical College,
			Beijing, China; Department of Respiratory
			Medicine, Capital Medical University, Beijing,
			China; Tsinghua University-Peking University
			Joint Center for Life Sciences, Beijing, China.
			Electronic address: caobin_ben@163.com.

			BACKGROUND: A recent cluster of pneumonia
			cases in Wuhan, China, was caused by a novel
			betacoronavirus, the
			2019 novel coronavirus (2019-nCoV).
			We report the epidemiological,
			clinical, laboratory, and radiological
			characteristics and treatment and clinical
			outcomes of these patients. METHODS: All
			patients with suspected 2019-nCoV were
			admitted to a designated hospital in Wuhan.
			We prospectively collected and analysed data
			on patients with laboratory-confirmed
			2019-nCoV infection by real-time RT-PCR and
			next-generation sequencing. Data were
			obtained with standardised data collection
			forms shared by the International Severe Acute
			Respiratory and Emerging Infection Consortium
			from electronic medical records. Researchers
			also directly communicated with patients or
			their families to ascertain epidemiological and
			symptom data. Outcomes were also compared
			between patients who had been admitted to
			the intensive care unit (ICU) and those who had
			not. FINDINGS: By Jan 2, 2020, 41 admitted
			hospital patients had been identified as having
			laboratory-confirmed 2019-nCoV infection.
			Most of the infected patients were men (30
			[73%] of 41); less than half had underlying
			diseases (13 [32%]), including diabetes (eight
			[20%]), hypertension (six [15%]), and
			cardiovascular disease (six [15%]). Median age
			was 49·0 years (IQR 41·0-58·0). 27 (66%) of 41
			patients had been exposed to Huanan seafood
			market. One family cluster was found. Common
			symptoms at onset of illness were fever (40
			[98%] of 41 patients), cough (31 [76%]), and
			myalgia or fatigue (18 [44%]); less common
			symptoms were sputum production (11 [28%]
			of 39), headache (three [8%] of 38),
			haemoptysis (two [5%] of 39), and diarrhoea
			(one [3%] of 38). Dyspnoea developed in 22
			(55%) of 40 patients (median time from illness
			onset to dyspnoea 8·0 days [IQR 5·0-13·0]). 26
			(63%) of 41 patients had lymphopenia. All 41
			patients had pneumonia with abnormal findings
			on chest CT. Complications included
			acute respiratory distress syndrome (12 [29%]),
			RNAaemia (six [15%]), acute cardiac injury (five
			[12%]) and secondary infection (four [10%]). 13
			(32%) patients were admitted to an ICU and six
			(15%) died. Compared with non-ICU patients,
			ICU patients had higher plasma levels of IL2,
			IL7, IL10, GSCF, IP10, MCP1, MIP1A, and
			TNFα. INTERPRETATION: The 2019-nCoV
			infection caused clusters of severe respiratory
			illness similar to
			severe acute respiratory syndrome coronavirus
			and was associated with ICU admission and
			high mortality. Major gaps in our knowledge of
			the origin, epidemiology, duration of human
			transmission, and clinical spectrum of disease
			need fulfilment by future studies. FUNDING:
			Ministry of Science and Technology,
			Chinese Academy of Medical Sciences,
			National Natural Science Foundation of China,
			and Beijing Municipal Science and Technology
			Commission.

			Copyright © 2020 Elsevier Ltd. All rights
			reserved.

			DOI: 10.1016/S0140-6736(20)30183-5
			PMID: 31986264

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