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			PubMed Journals: Annu Rev Microbiol

  Source:		PMID: 31226023


    		Annu Rev Microbiol. 2019 Jun 21. doi:
     		10.1146/annurev-micro-020518-115759. [Epub
			ahead of print]

			Human Coronavirus: Host-Pathogen Interaction.


			Fung TS(1), Liu DX(1).

			Author Information
			(1) Guangdong Province Key Laboratory of
			Microbial Signals and Disease Control and
			Integrative Microbiology Research Centre,
			South China Agricultural University, Guangzhou
			510642, Guangdong, People's Republic of
			China; email: dxliu0001@163.com.

			Human coronavirus (HCoV) infection causes
			respiratory diseases with mild to severe
			outcomes. In the last 15 years, we have
			witnessed the emergence of two zoonotic, highly
			pathogenic HCoVs: severe acute respiratory syndrome
			coronavirus (SARS-CoV) and
			Middle East respiratory syndrome coronavirus
			(MERS-CoV). Replication of HCoV is regulated
			by a diversity of host factors and induces
			drastic alterations in cellular structure
			and physiology. Activation of critical
			signaling pathways during HCoV infection
			modulates the induction of antiviral immune
			response and contributes to the pathogenesis
			of HCoV. Recent studies have begun to reveal
			some fundamental aspects of the intricate HCoV-host
			interaction in mechanistic detail. In this
			review, we summarize the current knowledge
			of host factors co-opted and signaling pathways
			activated during HCoV infection, with an
			emphasis on HCoV-infection-induced stress
			response, autophagy, apoptosis, and innate immunity.
			The cross talk among these pathways, as
			well as the modulatory strategies utilized
			by HCoV are also discussed. Expected final
			online publication date for the Annual Review
			of Microbiology Volume 73 is September 9,
			2019. Please see
			http://www.annualreviews.org/page/journal/pubdates
			for revised estimates.

			DOI: 10.1146/annurev-micro-020518-115759
			PMID: 31226023

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