PubMed Journals: Annu Rev Microbiol
Source: PMID: 31226023⇦⇨ Annu Rev Microbiol. 2019 Jun 21. doi:
ahead of print]
Human Coronavirus: Host-Pathogen Interaction.
Fung TS(1), Liu DX(1).
(1) Guangdong Province Key Laboratory of
Microbial Signals and Disease Control and
Integrative Microbiology Research Centre,
South China Agricultural University, Guangzhou
510642, Guangdong, People's Republic of
China; email: email@example.com.
Human coronavirus (HCoV) infection causes
respiratory diseases with mild to severe
outcomes. In the last 15 years, we have
witnessed the emergence of two zoonotic, highly
pathogenic HCoVs: severe acute respiratory syndrome
coronavirus (SARS-CoV) and
Middle East respiratory syndrome coronavirus
(MERS-CoV). Replication of HCoV is regulated
by a diversity of host factors and induces
drastic alterations in cellular structure
and physiology. Activation of critical
signaling pathways during HCoV infection
modulates the induction of antiviral immune
response and contributes to the pathogenesis
of HCoV. Recent studies have begun to reveal
some fundamental aspects of the intricate HCoV-host
interaction in mechanistic detail. In this
review, we summarize the current knowledge
of host factors co-opted and signaling pathways
activated during HCoV infection, with an
emphasis on HCoV-infection-induced stress
response, autophagy, apoptosis, and innate immunity.
The cross talk among these pathways, as
well as the modulatory strategies utilized
by HCoV are also discussed. Expected final
online publication date for the Annual Review
of Microbiology Volume 73 is September 9,
2019. Please see
for revised estimates.
DOI: 10.1146/annurev-micro-020518-115759PMID: 31226023⇧TweetPrint