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			PubMed Journals: Semin Diagn Pathol

  Source:		PMID: 31054790


    		Semin Diagn Pathol. 2019 May;36(3):152-159.
     		doi: 10.1053/j.semdp.2019.04.006. Epub 2019
			Apr 17.

			Emerging respiratory infections: The infectious
			disease pathology of SARS, MERS, pandemic
			influenza, and Legionella.

			Bradley BT(1), Bryan A(2).

			Author Information
			(1) University of Washington, Department
			of Laboratory Medicine, Box 357110, 1959
			NE Pacific Street, NW120, Seattle, WA 98195-7110,
			United States.
			(2) University of Washington, Department
			of Laboratory Medicine, Box 357110, 1959
			NE Pacific Street, NW120, Seattle, WA 98195-7110,
			United States. Electronic address: andrewbb@uw.edu.

			Lower respiratory infections remain one
			of the top global causes of death and the
			emergence of new diseases continues to be
			a concern. In the first two decades of the
			21st century, we have born witness to the
			emergence of newly recognized coronaviruses
			that have rapidly spread around the globe,
			including severe acute respiratory syndrome
			virus (SARS) and Middle Eastern respiratory
			syndrome virus (MERS). We have also experienced
			the emergence of a novel H1N1 pandemic influenza
			strain in 2009 that caused substantial morbidity
			and mortality around the world and has transitioned
			into a seasonal strain. Although we perhaps
			most frequently think of viruses when discussing
			emerging respiratory infections, bacteria
			have not been left out of the mix, as we
			have witnessed an increase in the number
			of infections from Legionella spp. since the organisms'
			initial discovery in 1976. Here, we explore
			the basic epidemiology, clinical presentation, histopathology,
			and clinical laboratory diagnosis of these
			four pathogens and emphasize themes in humans'
			evolving relationship with our natural environment
			that have contributed to the infectious
			burden. Histology alone is rarely diagnostic
			for these infections, but has been crucial
			to bettering our understanding of these
			diseases. Together, we rely on the diagnostic
			acumen of pathologists to identify the
			clinicopathologic features that raise the
			suspicion of these diseases and lead to
			the early control of the spread in our populations.

			Copyright © 2019 Elsevier Inc. All rights
			reserved.

			DOI: 10.1053/j.semdp.2019.04.006 PMID: 31054790

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