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			PubMed Journals: Front Microbiol

  Source:		PMID: 30984127


    		Front Microbiol. 2019 Mar 26;10:569. doi:
     		10.3389/fmicb.2019.00569. eCollection 2019.

			Recent Aspects on the Pathogenesis Mechanism,
			Animal Models and Novel Therapeutic Interventions
			for Middle East Respiratory Syndrome
			Coronavirus Infections.

			Skariyachan S(1), Challapilli SB(1), Packirisamy
			S(1), Kumargowda ST(1), Sridhar VS(1).

			Author Information
			(1) R&D Centre, Department of Biotechnology,
			Dayananda Sagar College of Engineering,
			Bengaluru, India.

			Middle East Respiratory Syndrome Coronavirus
			(MERS-CoV) is an emerging zoonotic virus
			considered as one of the major public threat
			with a total number of 2 298 laboratory-confirmed
			cases and 811 associated deaths reported
			by World Health Organization as of January
			2019. The transmission of the virus was
			expected to be from the camels found in
			Middle Eastern countries via the animal
			and human interaction. The genome structure
			provided information about the pathogenicity
			and associated virulent factors present
			in the virus. Recent studies suggested that
			there were limited insight available on
			the development of novel therapeutic strategies
			to induce immunity against the virus. The
			severities of MERS-CoV infection highlight
			the necessity of effective approaches for
			the development of various therapeutic remedies.
			Thus, the present review comprehensively
			and critically illustrates the recent aspects
			on the epidemiology of the virus, the structural
			and functional features of the viral genome,
			viral entry and transmission, major mechanisms
			of pathogenesis and associated virulent
			factors, current animal models, detection
			methods and novel strategies for the development
			of vaccines against MERS-CoV. The review
			further illustrates the molecular and computational
			virtual screening platforms which provide
			insights for the identification of putative
			drug targets and novel lead molecules toward
			the development of therapeutic remedies.

			DOI: 10.3389/fmicb.2019.00569 PMCID: PMC6448012
			PMID: 30984127

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