PubMed Journals: Curr Genomics
Source: PMID: 27047253
⇦ ⇨ Curr Genomics. 2015 Oct;16(5):327-35. doi:
RNA Viruses: RNA Roles in Pathogenesis,
Coreplication and Viral Load.
Poltronieri P(1), Sun B(2), Mallardo M(3).
(1) CNR-ISPA, Institute of Sciences of Food
Productions, National Research Council of
Italy, Lecce, Italy;
(2) Research Group of HIV Molecular Epidemiology
and Virology, Wuhan Institute of Virology,
Chinese Academy of Sciences, Wuhan, Hubei
430071, PR China;
(3) Department of Molecular Medicine and
Medical Biotechnology, University of Naples
Federico II°, Napoli, Italy.
The review intends to present and recapitulate
the current knowledge on the roles and importance
of regulatory RNAs, such as microRNAs and
small interfering RNAs, RNA binding proteins
and enzymes processing RNAs or activated
by RNAs, in cells infected by RNA viruses.
The review focuses on how non-coding RNAs
are involved in RNA virus replication, pathogenesis
and host response, especially in retroviruses
HIV, with examples of the mechanisms of
action, transcriptional regulation, and
promotion of increased stability of their
targets or their degradation.
PMCID: PMC4763971 PMID: 27047253