PubMed Journals: Curr Genomics

  Source:		PMID: 27047253

    		Curr Genomics. 2015 Oct;16(5):327-35. doi:

			RNA Viruses: RNA Roles in Pathogenesis,
			Coreplication and Viral Load.

			Poltronieri P(1), Sun B(2), Mallardo M(3).

			Author Information
			(1) CNR-ISPA, Institute of Sciences of Food
			Productions, National Research Council of
			Italy, Lecce, Italy;
			(2) Research Group of HIV Molecular Epidemiology
			and Virology, Wuhan Institute of Virology,
			Chinese Academy of Sciences, Wuhan, Hubei
			430071, PR China;
			(3) Department of Molecular Medicine and
			Medical Biotechnology, University of Naples
			Federico IIĀ°, Napoli, Italy.

			The review intends to present and recapitulate
			the current knowledge on the roles and importance
			of regulatory RNAs, such as microRNAs and
			small interfering RNAs, RNA binding proteins
			and enzymes processing RNAs or activated
			by RNAs, in cells infected by RNA viruses.
			The review focuses on how non-coding RNAs
			are involved in RNA virus replication, pathogenesis
			and host response, especially in retroviruses
			HIV, with examples of the mechanisms of
			action, transcriptional regulation, and
			promotion of increased stability of their
			targets or their degradation.

			DOI: 10.2174/1389202916666150707160613
			PMCID: PMC4763971 PMID: 27047253

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