PubMed Journals: Chang Gung Med J
Source: PMID: 22537926
⇦ ⇨ Chang Gung Med J. 2012 Mar-Apr;35(2):111-24.
Host factors in the replication of positive-strand
Wang RY(1), Li K.
(1) Department of Biomedical Sciences,
Chang Gung University, Taoyuan, Taiwan.
Viruses are obligate, intracellular parasites
that depend on host cells for successful
propagation. Upon infection of host cells,
positivestrand RNA viruses exploit and hijack
cellular machinery and reprogram these cells
into viral "factories" through various
protein-protein, protein- RNA, and protein-lipid
interactions. The molecular interplay between
host factors and invading viruses is a continuous
process throughout the entire viral life
cycle and determines virus host range and viral
pathogenesis, as well as driving viral evolution.
Studies of host factors have contributed
insights into their normal cellular functions
and helped identify attractive targets for
antiviral drug development. With the development
of high throughput screening, functional
genomics, and proteomics technologies, host
factors participating in viral life cycles
have been identified rapidly in recent years.
In this review, we summarize the recent
advances in virus-host cell interactions
in positive-strand RNA virus infections
and focus on host factors that facilitate
PMID: 22537926 [Indexed for MEDLINE]