PubMed Journals: Chang Gung Med J

  Source:		PMID: 22537926

    		Chang Gung Med J. 2012 Mar-Apr;35(2):111-24.
			Host factors in the replication of positive-strand
			RNA viruses.

			Wang RY(1), Li K.

			Author Information
			(1) Department of Biomedical Sciences,
			Chang Gung University, Taoyuan, Taiwan.

			Viruses are obligate, intracellular parasites
			that depend on host cells for successful
			propagation. Upon infection of host cells,
			positivestrand RNA viruses exploit and hijack
			cellular machinery and reprogram these cells
			into viral "factories" through various
			protein-protein, protein- RNA, and protein-lipid
			interactions. The molecular interplay between
			host factors and invading viruses is a continuous
			process throughout the entire viral life
			cycle and determines virus host range and viral
			pathogenesis, as well as driving viral evolution.
			Studies of host factors have contributed
			insights into their normal cellular functions
			and helped identify attractive targets for
			antiviral drug development. With the development
			of high throughput screening, functional
			genomics, and proteomics technologies, host
			factors participating in viral life cycles
			have been identified rapidly in recent years.
			In this review, we summarize the recent
			advances in virus-host cell interactions
			in positive-strand RNA virus infections
			and focus on host factors that facilitate
			viral replication.

			PMID: 22537926 [Indexed for MEDLINE]

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