PubMed Journals: Am J Trop Med Hyg

  Source:		PMID: 18385368
  Download:	http://www.ajtmh.org/docserver/fulltext/14761645/78/4/0780675.pdf

    		Am J Trop Med Hyg. 2008 Apr;78(4):675-80.
			Dhori virus (Orthomyxoviridae: Thogotovirus)
			infection of mice produces a disease and
			cytokine response pattern similar to that
			of highly virulent influenza A (H5N1) virus
			infection in humans.

			Li G(1), Wang N, Guzman H, Sbrana E, Yoshikawa
			T, Tseng CT, Tesh RB, Xiao SY.

			Author Information
			(1) Department of Pathology, University
			of Texas Medical Branch, Galveston, Texas
			77555-0609, USA.

			Mice infected with Dhori virus (DHOV) develop
			a fulminant, systemic, and uniformly fatal
			illness that has many of the clinical and
			pathologic findings seen in H5N1 influenza
			A virus infection. However, the role of
			host's immune response in DHOV infection
			remains unclear. In this study, the concentrations
			of 23 inflammatory cytokines and chemokines
			were measured in the liver, lungs, and sera
			of mice during the course of DHOV infection.
			Liver function, level of viremia, and hematologic
			response were also monitored. Infected animals
			exhibited significant leucopenia and lymphopenia,
			which directly correlated with the disease
			progression. High yields of infectious virus
			along with strikingly elevated expression
			of various inflammatory mediators, including
			tumor necrosis factor (TNF)-alpha, interleukin
			(IL)-1, IL-6, IL-10, macrophage inflammatory
			protein (MIP)-1alpha, manocyte chemoattractant protein
			(MCP)-1, and interferon (IFN)-alpha, indicate
			that these responses play an important role
			in the observed disease and pathology. The
			overall clinical, pathologic, and immunologic
			responses of ICR mice to DHOV infection
			closely resemble those described for highly
			virulent influenza A virus infection in
			humans, thereby offering a realistic, safe,
			and alternative animal model for studying
			the pathogenesis and treatment of highly
			pathogenic avian influenza virus.

			PMID: 18385368 [Indexed for MEDLINE]

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