PubMed Journals: Am J Trop Med Hyg

  Source:		PMID: 17426188
  Download:	http://www.ajtmh.org/docserver/fulltext/14761645/76/4/0760785.pdf

    		Am J Trop Med Hyg. 2007 Apr;76(4):785-90.
			Dhori virus (Orthomyxoviridae: Thogotovirus)
			infection in mice: a model of the pathogenesis
			of severe orthomyxovirus infection.

			Mateo RI(1), Xiao SY, Lei H, DA Rosa AP,
			Tesh RB.

			Author Information
			(1) Department of Pathology and Center for
			Biodefense and Emerging Infectious Diseases,
			University of Texas Medical Branch, Galveston,
			Texas 77555, USA.

			After intranasal, subcutaneous, or intraperitoneal
			infection with Dhori virus (DHOV), adult
			mice developed a fulminant and uniformly
			fatal illness with many of the clinical
			and pathologic findings seen in mice infected
			with H5N1 highly pathogenic avian influenza
			A virus. Histopathologic findings in lungs
			of DHOV-infected mice consisted of hemorrhage,
			inflammation, and thickening of the interstitium
			and the alveolar septa and alveolar edema.
			Extra-pulmonary findings included hepatocellular necrosis
			and steatosis, widespread severe fibrinoid
			necrosis in lymphoid organs, marked lymphocyte
			loss and karyorrhexis, and neuronal degeneration
			in brain. Similar systemic histopathologic
			findings have been reported in the few fatal
			human H5N1 cases examined at autopsy. Because
			of the relationship of DHOV to the influenza
			viruses, its biosafety level 2 status, and
			its similar pathology in mice, the DHOV-mouse
			model may offer a low-cost, relatively safe,
			and realistic animal model for studies on
			the pathogenesis and management of H5N1
			virus infection.

			PMID: 17426188 [Indexed for MEDLINE]

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