PubMed Journals: Virology

  Source:		PMID: 17316733
  Download:	https://www.sciencedirect.com/science/article/pii/S004268220700044X

    		Virology. 2007 Apr 25;361(1):18-26. Epub
     		2007 Feb 21.

			Group 2 coronaviruses prevent immediate
			early interferon induction by protection
			of viral RNA from host cell recognition.

			Versteeg GA(1), Bredenbeek PJ, van den Worm
			SH, Spaan WJ.

			Author Information
			(1) Molecular Virology Laboratory, Department
			of Medical Microbiology, Center of Infectious
			Diseases, Leiden University Medical Center,
			LUMC E4-P, P.O. Box 9600, 2300 RC Leiden,
			The Netherlands.

			Many viruses encode antagonists to prevent
			interferon (IFN) induction. Infection of
			fibroblasts with the murine hepatitis coronavirus
			(MHV) and SARS-coronavirus (SARS-CoV) did not result
			in nuclear translocation of
			interferon-regulatory factor 3 (IRF3), a
			key transcription factor involved in IFN
			induction, and induction of IFN mRNA transcription.
			Furthermore, MHV and SARS-CoV infection
			could not prevent IFN induction by poly
			(I:C) or Sendai virus, suggesting that these
			CoVs do not inactivate IRF3-mediated transcription
			regulation, but apparently prevent detection
			of replicative RNA by cellular sensory molecules.
			Our data indicate that shielding of viral
			RNA to host cell sensors might be the main
			general mechanism for coronaviruses to prevent
			IFN induction.

			DOI: 10.1016/j.virol.2007.01.020 PMID: 17316733
			[Indexed for MEDLINE]

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