PubMed Journals: Virology
Source: PMID: 16753195
⇦ ⇨ Virology. 2006 Aug 15;352(1):14-21. Epub
⇩ 2006 Jun 6.
Innate immune responses: crosstalk of signaling
and regulation of gene transcription.
Zhong B(1), Tien P, Shu HB.
(1) College of Life Sciences, Wuhan University,
Wuhan 430072, China.
Innate immune responses to pathogens such
as bacteria and viruses are triggered by
recognition of specific structures of invading
pathogens called pathogen-associated molecular
patterns (PAMPs) by cellular pattern recognition
receptors (PRRs) that are located at plasma
membrane or inside cells. Stimulation of
different PAMPs activates Toll-like receptor
(TLR)-dependent and -independent signaling
pathways that lead to activation of transcription
factors nuclear factor-kappaB (NF-kappaB),
interferon regulatory factor 3/7 (IRF3/7) and/or
activator protein-1 (AP-1), which collaborate
to induce transcription of a large number
of downstream genes. This review focuses
on the rapid progress that has recently
improved our understanding of the crosstalk
among the pathways and the precise regulation
of transcription of the downstream genes.
DOI: 10.1016/j.virol.2006.04.029 PMID: 16753195
[Indexed for MEDLINE]