PubMed Journals: Virology

  Source:		PMID: 16753195
  Download:	https://reader.elsevier.com/reader/sd/pii/S0042682206002893

    		Virology. 2006 Aug 15;352(1):14-21. Epub
     		2006 Jun 6.

			Innate immune responses: crosstalk of signaling
			and regulation of gene transcription.

			Zhong B(1), Tien P, Shu HB.

			Author Information
			(1) College of Life Sciences, Wuhan University,
			Wuhan 430072, China.

			Innate immune responses to pathogens such
			as bacteria and viruses are triggered by
			recognition of specific structures of invading
			pathogens called pathogen-associated molecular
			patterns (PAMPs) by cellular pattern recognition
			receptors (PRRs) that are located at plasma
			membrane or inside cells. Stimulation of
			different PAMPs activates Toll-like receptor
			(TLR)-dependent and -independent signaling
			pathways that lead to activation of transcription
			factors nuclear factor-kappaB (NF-kappaB),
			interferon regulatory factor 3/7 (IRF3/7) and/or
			activator protein-1 (AP-1), which collaborate
			to induce transcription of a large number
			of downstream genes. This review focuses
			on the rapid progress that has recently
			improved our understanding of the crosstalk
			among the pathways and the precise regulation
			of transcription of the downstream genes.

			DOI: 10.1016/j.virol.2006.04.029 PMID: 16753195
			[Indexed for MEDLINE]

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