PubMed Journals: Cell Res
Source: PMID: 16474426
⇦ ⇨ Cell Res. 2006 Feb;16(2):141-7.
Antiviral innate immunity pathways.
Seth RB(1), Sun L, Chen ZJ.
(1) Howard Hughes Medical Institute, Department
of Molecular Biology,
University of Texas Southwestern Medical Center,
Dallas, TX 75390-9148, USA.
Recent studies have uncovered two signaling
pathways that activate the host innate immunity
against viral infection. One of the pathways
utilizes members of the Toll-like receptor
(TLR) family to detect viruses that enter
the endosome through endocytosis. The TLR
pathway induces interferon production through
several signaling proteins that ultimately
lead to the activation of the transcription
factors NF-kappaB, IRF3 and IRF7. The other
antiviral pathway uses the RNA helicase
RIG-I as the receptor for intracellular
viral double-stranded RNA. RIG-I activates
NF-kappaB and IRFs through the recently
identified adaptor protein MAVS, a CARD domain
containing protein that resides in the mitochondrial
membrane. MAVS is essential for antiviral
innate immunity, but it also serves as a
target of Hepatitis C virus (HCV), which
employs a viral protease to cleave MAVS
off the mitochondria, thereby allowing HCV
to escape the host immune system.
DOI: 10.1038/sj.cr.7310019 PMID: 16474426
[Indexed for MEDLINE]