PubMed Journals: Cell Mol Life Sci

  Source:		PMID: 15316659
  Download:	https://link.springer.com/content/pdf/10.1007/s00018-004-4222-9.pdf

    		Cell Mol Life Sci. 2004 Aug;61(16):2100-12.
			Infection of cultured intestinal epithelial
			cells with severe acute respiratory syndrome

			Cinatl J Jr(1), Hoever G, Morgenstern B,
			Preiser W, Vogel JU, Hofmann WK, Bauer G,
			Michaelis M, Rabenau HF, Doerr HW.

			Author Information
			(1) Institute for Medical Virology,
			Johann Wolfgang Goethe University
			Hospital, Paul-Ehrlich Str. 40, 60596,
			Frankfurt am Main, Germany.

			To identify a model for the study of intestinal
			pathogenesis of severe acute respiratory syndrome
			(SARS) we tested the sensitivity
			of six human intestinal epithelial cell
			lines to infection with SARS coronavirus
			(SARS-CoV). In permissive cell lines, effects
			of SARS-CoV on cellular gene expression
			were analysed using high-density oligonucleotide
			arrays. Caco-2 and CL-14 cell lines were
			found to be highly permissive to SARS-CoV,
			due to the presence of angiotensin-converting
			enzyme 2 as a functional receptor. In both
			cell lines, SARS-CoV infection deregulated
			expression of cellular genes which may be
			important for the intestinal pathogenesis
			of SARS.

			DOI: 10.1007/s00018-004-4222-9 PMID: 15316659
			[Indexed for MEDLINE]

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