PubMed Journals: Emerg Infect Dis
Source: PMID: 15030704
⇦ ⇨ Emerg Infect Dis. 2004 Feb;10(2):317-9.
Interferon-beta 1a and SARS coronavirus
Hensley LE(1), Fritz LE, Jahrling PB, Karp
CL, Huggins JW, Geisbert TW.
(1) Virology Division, US Army Medical Research
Institute of Infectious Diseases, Fort Detrick,
Maryland 21702, USA.
A global outbreak of severe acute respiratory syndrome
(SARS) caused by a novel coronavirus
began in March 2003. The rapid emergence
of SARS and the substantial illness and
death it caused have made it a critical
public health issue. Because no effective
treatments are available, an intensive effort
is under way to identify and test promising
antiviral drugs. Here, we report that recombinant
human interferon-beta 1a potently inhibits
SARS coronavirus replication in vitro.
DOI: 10.3201/eid1002.030482 PMCID: PMC3322919
PMID: 15030704 [Indexed for MEDLINE]