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			PubMed Journals: Chin Med J (Engl)

  Source:		PMID: 12890365


    		Chin Med J (Engl). 2003 Jul;116(7):976-80.
     
			Pathological study on
			severe acute respiratory syndrome.

			Lang Z(1), Zhang L, Zhang S, Meng X, Li
			J, Song C, Sun L, Zhou Y.

			Author Information
			(1) Department of Pathology, Beijing Youan
			Hospital, Capital University of Medical
			Sciences, Beijing 100054, China.

			OBJECTIVE: To study the pathological characteristics
			of severe acute respiratory syndrome (SARS)
			and its relationship to clinical manifestation.
			METHODS: Tissue specimens from 3 autopsies of
			probable SARS cases were studied by microscope,
			and the clinical data was reviewed. RESULTS:
			The typical pathological changes of lungs
			were diffuse hemorrhaging on the surface. A combination
			of serous, fibrinous and hemorrhagic inflammation
			was seen in most of the pulmonary alveoli
			with the engorgement of capillaries and
			detection of micro-thrombosis in some of these
			capillaries. Pulmonary alveoli thickened
			with interstitial mononuclear inflammatory
			infiltrates, suffered diffuse alveolar damage,
			experienced desquamation of pneumocytes
			and had hyaline-membrane formation, fibrinoid
			materials, and erythrocytes in alveolar
			spaces. There were thromboembolisms in some
			bronchial arteries. Furthermore, hemorrhagic
			necrosis was also evident in lymph nodes
			and spleen with the attenuation of lymphocytes.
			Other atypical pathological changes, such
			as hydropic degeneration, fatty degeneration,
			interstitial cell proliferation and lesions
			having existed before hospitalization were
			observed in the liver, heart, kidney and
			pancreas. CONCLUSION: Severe damage to the pulmonary
			and immunological systems is responsible
			for the clinical features of SARS and may
			lead to the death of patients.

			PMID: 12890365 [Indexed for MEDLINE]

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