PubMed Journals: Chin Med J (Engl)
Source: PMID: 12890365
⇦ ⇨ Chin Med J (Engl). 2003 Jul;116(7):976-80.
Pathological study on
severe acute respiratory syndrome.
Lang Z(1), Zhang L, Zhang S, Meng X, Li
J, Song C, Sun L, Zhou Y.
(1) Department of Pathology, Beijing Youan
Hospital, Capital University of Medical
Sciences, Beijing 100054, China.
OBJECTIVE: To study the pathological characteristics
of severe acute respiratory syndrome (SARS)
and its relationship to clinical manifestation.
METHODS: Tissue specimens from 3 autopsies of
probable SARS cases were studied by microscope,
and the clinical data was reviewed. RESULTS:
The typical pathological changes of lungs
were diffuse hemorrhaging on the surface. A combination
of serous, fibrinous and hemorrhagic inflammation
was seen in most of the pulmonary alveoli
with the engorgement of capillaries and
detection of micro-thrombosis in some of these
capillaries. Pulmonary alveoli thickened
with interstitial mononuclear inflammatory
infiltrates, suffered diffuse alveolar damage,
experienced desquamation of pneumocytes
and had hyaline-membrane formation, fibrinoid
materials, and erythrocytes in alveolar
spaces. There were thromboembolisms in some
bronchial arteries. Furthermore, hemorrhagic
necrosis was also evident in lymph nodes
and spleen with the attenuation of lymphocytes.
Other atypical pathological changes, such
as hydropic degeneration, fatty degeneration,
interstitial cell proliferation and lesions
having existed before hospitalization were
observed in the liver, heart, kidney and
pancreas. CONCLUSION: Severe damage to the pulmonary
and immunological systems is responsible
for the clinical features of SARS and may
lead to the death of patients.
PMID: 12890365 [Indexed for MEDLINE]