PubMed Journals: Gene
Source: PMID: 12039028
⇦ ⇨ Gene. 2002 Feb 20;285(1-2):1-24.
Signaling through the JAK/STAT pathway, recent
advances and future challenges.
Kisseleva T(1), Bhattacharya S, Braunstein
J, Schindler CW.
(1) Department of Microbiology, College
of Physicians and Surgeons, Columbia University,
New York, NY 10032, USA.
Investigation into the mechanism of cytokine
signaling led to the discovery of the JAK/STAT
pathway. Following the binding of cytokines
to their cognate receptor, signal transducers
and activators of transcription (STATs)
are activated by members of the janus activated
kinase (JAK) family of tyrosine kinases.
Once activated, they dimerize and translocate
to the nucleus and modulate the expression
of target genes. During the past several
years significant progress has been made
in the characterization of the JAK/STAT
signaling cascade, including the identification
of multiple STATs and regulatory proteins.
Seven STATs have been identified in mammals.
The vital role these STATs play in the biological
response to cytokines has been demonstrated
through the generation of murine 'knockout'
models. These mice will be invaluable in
carefully elucidating the role STATs play
in regulating the host response to various
stresses. Similarly, the solution of the
crystal structure of two STATs has and will
continue to facilitate our understanding
of how STATs function. This review will
highlight these exciting developments in
PMID: 12039028 [Indexed for MEDLINE]