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			PubMed Journals: Gene

  Source:		PMID: 12039028
  Download:	https://www.sciencedirect.com/science/article/abs/pii/S0378111902003980

    		Gene. 2002 Feb 20;285(1-2):1-24.
     
			Signaling through the JAK/STAT pathway, recent
			advances and future challenges.

			Kisseleva T(1), Bhattacharya S, Braunstein
			J, Schindler CW.

			Author Information
			(1) Department of Microbiology, College
			of Physicians and Surgeons, Columbia University,
			New York, NY 10032, USA.

			Investigation into the mechanism of cytokine
			signaling led to the discovery of the JAK/STAT
			pathway. Following the binding of cytokines
			to their cognate receptor, signal transducers
			and activators of transcription (STATs)
			are activated by members of the janus activated
			kinase (JAK) family of tyrosine kinases.
			Once activated, they dimerize and translocate
			to the nucleus and modulate the expression
			of target genes. During the past several
			years significant progress has been made
			in the characterization of the JAK/STAT
			signaling cascade, including the identification
			of multiple STATs and regulatory proteins.
			Seven STATs have been identified in mammals.
			The vital role these STATs play in the biological
			response to cytokines has been demonstrated
			through the generation of murine 'knockout'
			models. These mice will be invaluable in
			carefully elucidating the role STATs play
			in regulating the host response to various
			stresses. Similarly, the solution of the
			crystal structure of two STATs has and will
			continue to facilitate our understanding
			of how STATs function. This review will
			highlight these exciting developments in
			JAK/STAT signaling.

			PMID: 12039028 [Indexed for MEDLINE]

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