PubMed Journals: Science
Source: PMID: 11951031
⇦ ⇨ Science. 2002 Apr 12;296(5566):298-300.
Decoding the patterns of self and nonself
by the innate immune system.
Medzhitov R(1), Janeway CA Jr.
(1) Howard Hughes Medical Institute and
Section of Immunobiology, Yale University
School of Medicine, New Haven, CT 06520,
The innate immune system evolved several
strategies of self/nonself discrimination
that are based on the recognition of molecular
patterns demarcating infectious nonself,
as well as normal and abnormal self. These
patterns are deciphered by receptors that
either induce or inhibit an immune response,
depending on the meaning of these signals.
DOI: 10.1126/science.1068883 PMID: 11951031
[Indexed for MEDLINE]