PubMed Journals: FEBS Lett
Source: PMID: 11257495
⇦ ⇨ FEBS Lett. 2001 Mar 16;492(3):204-9.
A new family of small, palmitoylated,
membrane-associated proteins, characterized
by the presence of a cysteine-rich hydrophobic
Cools J(1), Mentens N, Marynen P.
(1) The Human Genome Laboratory, Center
for Human Genetics, University of Leuven,
Flanders Interuniversity Institute for Biotechnology
(VIB), Herestraat 49, B-3000, Leuven, Belgium.
We recently cloned the CHIC2 gene (previously
BTL) by virtue of its involvement in a chromosomal
translocation t(4;12)(q11;p13) occurring
in acute myeloid leukemias. In this study
we show that CHIC2 is a member of a highly
conserved family of proteins characterized
by the presence of a striking cysteine-rich
hydrophobic (CHIC) motif. Our data illustrate
that cysteines in this central CHIC motif
are palmitoylated and that CHIC2 is associated
with vesicular structures and the plasma
membrane. The CHIC proteins thus resemble
the cysteine string proteins, which function
in regulated exocytosis.
PMID: 11257495 [Indexed for MEDLINE]