PubMed Journals: FEBS Lett

  Source:		PMID: 11257495

    		FEBS Lett. 2001 Mar 16;492(3):204-9.
			A new family of small, palmitoylated,
			membrane-associated proteins, characterized
			by the presence of a cysteine-rich hydrophobic

			Cools J(1), Mentens N, Marynen P.

			Author Information
			(1) The Human Genome Laboratory, Center
			for Human Genetics, University of Leuven,
			Flanders Interuniversity Institute for Biotechnology
			(VIB), Herestraat 49, B-3000, Leuven, Belgium.

			We recently cloned the CHIC2 gene (previously
			BTL) by virtue of its involvement in a chromosomal
			translocation t(4;12)(q11;p13) occurring
			in acute myeloid leukemias. In this study
			we show that CHIC2 is a member of a highly
			conserved family of proteins characterized
			by the presence of a striking cysteine-rich
			hydrophobic (CHIC) motif. Our data illustrate
			that cysteines in this central CHIC motif
			are palmitoylated and that CHIC2 is associated
			with vesicular structures and the plasma
			membrane. The CHIC proteins thus resemble
			the cysteine string proteins, which function
			in regulated exocytosis.

			PMID: 11257495 [Indexed for MEDLINE]

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